Timeline for Defining methylation level of CpG island
Current License: CC BY-SA 4.0
9 events
| when toggle format | what | by | license | comment | |
|---|---|---|---|---|---|
| Oct 14, 2020 at 2:03 | comment | added | M__♦ | Thanks @PaulEndymion a detailed adn useful response | |
| Sep 9, 2020 at 13:17 | comment | added | Paul Endymion | Well as you may know the effect of methylation on genes expression is far from being clear, most studies showing poor negative correlation between differential gene expression and methylation. An interesting approach was the one of Vanderkraats in doi.org/10.1093/nar/gkt482. The main idea was to look for pattern of differential methylation around genes promotor that could explain genes expression. | |
| Sep 9, 2020 at 9:04 | comment | added | unicorn | Yes, most current studies use DMR to measure methylation level. However, DNA methylation impose its impact by suppressing gene expression. I think it is more reasonable to measure the magnitude of methylation impact on gene expression than merely defining statistically methylated region. To do this, we may need better understanding on the correlation between methylation and mRNA expression (things like whether different CpG site have equal contribution on the expression of corresponding gene) | |
| Sep 8, 2020 at 16:22 | history | edited | Paul Endymion | CC BY-SA 4.0 |
deleted 6 characters in body
|
| Sep 8, 2020 at 14:04 | history | edited | Paul Endymion | CC BY-SA 4.0 |
edited body
|
| Sep 8, 2020 at 10:39 | history | edited | Paul Endymion | CC BY-SA 4.0 |
deleted 5 characters in body
|
| Sep 8, 2020 at 10:31 | history | edited | Paul Endymion | CC BY-SA 4.0 |
added 2 characters in body
|
| Sep 8, 2020 at 10:22 | history | edited | Paul Endymion | CC BY-SA 4.0 |
deleted 4 characters in body
|
| Sep 8, 2020 at 10:11 | history | answered | Paul Endymion | CC BY-SA 4.0 |