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Sep 30 '20 at 11:28 history edited gringer CC BY-SA 4.0
Removed unnecessary text
Sep 29 '20 at 8:10 answer llrs timeline score: 2
Sep 28 '20 at 14:58 comment added Reilstein Okay yeah that makes sense for how to obtain differences in the response, but then how might I statistically compare these differences in response for a group of genes (I.e a gene set)? Would you just do something simple like a t test / Wilcox test?
Sep 28 '20 at 14:26 comment added rpolicastro They want you to find genes whose response to the drug is different based on the genotype? If so, you can add an interaction term to your DESeq2 regression formula ~ condition + genotype + condition:genotype. Refer to the DESeq2 documentation and help("results", package="DESeq2") for more information on multifactor design and interaction terms.
Sep 27 '20 at 22:41 history asked Reilstein CC BY-SA 4.0