• Q1. How to handle the situation when there are divergences between a GenBank file and an actual or theoretical molecule:

  • Should the difference be indicated in the feature table? If so, with which feature key? And if not, how should it be indicated or what should be done?

  • Further, when indicating a divergence with a feature key, which should be considered the reference: the file or the molecule?

• Q2. How to keep track of changes between versions of a GenBank file when corrections or updates are made?

I have thus re-titled the question accordingly.

Also, by making further researches into the issues, I found what seems to me the appropriate solutions (see my answer below).

• Q1. How to handle the situation when there are divergences between a GenBank file and an actual or theoretical molecule:

  • Should the difference be indicated in the feature table? If so, with which feature key? And if not, how should it be indicated or what should be done?

  • Further, when indicating a divergence using a feature key, which should be considered the reference: the file or the molecule?

• Q2. How to keep track of changes between versions of a GenBank file when corrections or updates are made?

I have thus re-titled the question accordingly, and by making further researches into the issues I found what seems to me the appropriate solutions (see my answer below).