Timeline for Does AlphaFold actually calculate the fold?
Current License: CC BY-SA 4.0
14 events
| when toggle format | what | by | license | comment | |
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| S Aug 25 at 22:33 | history | edited | Ram RS | CC BY-SA 4.0 |
Typo in title and other edits
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| S Aug 25 at 22:33 | history | suggested | tripleee | CC BY-SA 4.0 |
Typo in title
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| Aug 25 at 17:54 | review | Suggested edits | |||
| S Aug 25 at 22:33 | |||||
| Aug 16 at 13:07 | history | bumped | CommunityBot | This question has answers that may be good or bad; the system has marked it active so that they can be reviewed. | |
| Apr 18 at 12:04 | history | bumped | CommunityBot | This question has answers that may be good or bad; the system has marked it active so that they can be reviewed. | |
| Dec 20, 2023 at 11:07 | history | bumped | CommunityBot | This question has answers that may be good or bad; the system has marked it active so that they can be reviewed. | |
| Nov 20, 2023 at 21:59 | comment | added | biocodz | '''the 3d structure of the DB target is the answer''' - this appears to be a fallacy | |
| Nov 20, 2023 at 15:28 | comment | added | biocodz | Your suggested formulation of 'retrieval' is very good. Using molecular dynamics to obtain the 3d structure would be a 'calculation'. My conceptual understanding of AF magic is that it 'calculates' the similarity between the primary structures of the query and a DB target with a known 3d structure ( (this calculation is non-trivial, and seems actually like the crux of the matter). Because similar sequences have similar folds, the 3d structure of the DB target is the answer. It is 'retrieval' because the answer is already known but getting it from the database is hard. | |
| Nov 20, 2023 at 10:36 | answer | added | M__♦ | timeline score: 1 | |
| Nov 19, 2023 at 20:08 | comment | added | Maximilian Press | When you say "calculate", what do you mean? is it "retrieval" when you summarize across a family of similar structures following a sophisticated evolutionary search, comparison, structure-sequence mapping computation, etc.? What's the degree and sophistication of that summary that would mean "calculate" and not "retrieve"? | |
| Nov 19, 2023 at 20:03 | history | edited | Maximilian Press |
edited tags
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| Nov 17, 2023 at 23:08 | comment | added | CommunityBot | Please clarify your specific problem or provide additional details to highlight exactly what you need. As it's currently written, it's hard to tell exactly what you're asking. | |
| S Nov 17, 2023 at 21:52 | review | First questions | |||
| Nov 17, 2023 at 23:08 | |||||
| S Nov 17, 2023 at 21:52 | history | asked | biocodz | CC BY-SA 4.0 |