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Jun 6, 2017 at 20:19 comment added Sarah Carl Fair point. But since olga did ask about advantages or disadvantages, I thought it would be worth mentioning. It might be useful in the future, or for other users, when merging files for other applications besides ChIP-seq, since samtools merge is widely used.
Jun 6, 2017 at 14:12 comment added ivivek_ngs I do not think one need @RG information for a ChIP-Seq , I mean it is very unlikely that someone would like to do a variants calling with ChIP-Seq. So in any case it it would hardly matter. I would just not mention about the @RG here since people might get confused.
Jun 6, 2017 at 8:19 history answered Sarah Carl CC BY-SA 3.0