I have 139 samples; In R for each sample I run below codes
for example for sample 1
sample_1 = whichSignatures(tumor.ref = sigs.input,
signatures.ref = signatures.nature2013,
sample.id = 1,
contexts.needed = TRUE,
tri.counts.method = 'genome')
a1=(sample_1[[1]])
> class(sample_1)
[1] "list"
> a1=(sample_1[[1]])
> head(a1)
Signature.1A Signature.1B Signature.2 Signature.3 Signature.4 Signature.5 Signature.6 Signature.7 Signature.8
1 0.5370653 0 0 0 0 0 0 0 0
Signature.9 Signature.10 Signature.11 Signature.12 Signature.13 Signature.14 Signature.15 Signature.16 Signature.17
1 0 0 0 0 0 0 0 0 0.3383947
Signature.18 Signature.19 Signature.20 Signature.21 Signature.R1 Signature.R2 Signature.R3 Signature.U1 Signature.U2
1 0.1123409 0 0 0 0 0 0 0 0
> dim(a1)
[1] 1 27
and for sample 2
sample_2 = whichSignatures(tumor.ref = sigs.input,
signatures.ref = signatures.nature2013,
sample.id = 2,
contexts.needed = TRUE,
tri.counts.method = 'genome')
a2=(sample_2[[1]])
And finally binding a1,a2,...a139
by
sig=rbind(a1,a2)
> print(sig)
Signature.1A Signature.1B Signature.2 Signature.3 Signature.4 Signature.5 Signature.6 Signature.7 Signature.8
1 0.5370653 0 0 0 0 0 0 0 0
2 0.7162292 0 0 0 0 0 0 0 0
Signature.9 Signature.10 Signature.11 Signature.12 Signature.13 Signature.14 Signature.15 Signature.16 Signature.17
1 0 0 0 0 0 0 0 0 0.3383947
2 0 0 0 0 0 0 0 0 0.2837708
Signature.18 Signature.19 Signature.20 Signature.21 Signature.R1 Signature.R2 Signature.R3 Signature.U1 Signature.U2
1 0.1123409 0 0 0 0 0 0 0 0
2 0.0000000 0 0 0 0 0 0 0 0
>
sigs.input
is a common R object here
Doing these manually is too painful; Can you please help me how I do that automatically in R? I am not sure but something like looping or whatever you guess possible
Thanks