I know that telomeres are highly repeated sequences, but is there any way to retain any reads that map to these regions (on HG38)?
I recently managed to find some protein binding to centromeres, which are also mainly repeats. Therefore I wondered if there was any way to pick up signal on the telomeres.
My team and I are investigating binding of a protein complex to DNA and the experimental team reported that they saw it a bit on telomeres, so we were wondering if there was any way to measure this through bioinformatics. If not then it's no problem, we would just like to know.