I have a list of cell lines that should be compared against another list of cell lines as pairs. I am trying to find a way in order for me to compare two cells such as MCF7 and 10964c cell lines. I am using python so, can anyone provide some steps so that I can do the comparison.
I also have their ontologies in an OBO format as I need them to do the comparison. if there is a library or a certain procedure that can solve this problem will be a great help.
The comparison I'm trying to do is to measure the similarity in different ways, there are many measurement methods such as the distance in the ontological hierarchy between two cells by calculating the shortest path. You can also measure the number of common ancestors. But also, there are libraries that perform complicated (and more accurate) similarity measurements like JiangConrath, Jaccard, or Resnik which is popular. The problem with theses libraries is that they are not oriented to calculate cell line ontologies and may arequire annotation corpus for some similarity measures.