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It is almost common sense that local amplification of gene increase the its mRNA expression . I recently heard that large scale SCNA (such as arm-level amplification) does not increase the mRNA expression level of gene within the region. I did some analysis (SCNA is determined by SNP array and NGS, mRNA expression is measured by RNA-Seq) and found that this is indeed the case. I further did some research and did not found any explanations. it seems like a common acknowledgement. Is there any technical bias or biological explanation that I am missing here? Or is it something that has not have a answer yet?

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  • $\begingroup$ The common presumption in such cases is that there's a feedback loop on most genes to control their expression level. $\endgroup$ – Devon Ryan Nov 26 '19 at 8:20
  • $\begingroup$ I am not sure if I understand you correctly. Do you mean there may be a specific feedback mechanism that inhibits expression during arm-level expression? If this is the case, do we have any cue how this feedback acts? $\endgroup$ – unicorn Nov 30 '19 at 2:20
  • $\begingroup$ It doesn't have to be specific to arm-level expression. $\endgroup$ – Devon Ryan Nov 30 '19 at 8:32
  • $\begingroup$ I have no cue about this at all. Can you recommend this papers on this? $\endgroup$ – unicorn Dec 1 '19 at 14:45

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