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I am working on cancer genomics failed to follow some terms even by googling

What is the difference of focal genome amplifications versus convergent amplification of given region of genome for instance fibroblast growth factors region?

Thank you for any clarification

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I think these definitions still have a degree of subjectivity and I don't think they are mutually exclusive.

Convergent amplification basically means that "similar" cancers/neoplasms have "similar" amplification patterns, i.e. at around the same loci (see Myllykangas S et al.,2006 for an example).

Focal genome amplification is defined as "CNA [copy number alteration] of limited size, frequently enriched for cancer driver genes" (Krijgsmanthis et al., 2014).

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