I have a
data.frame with results from a CRISPR screen.
I want to calculate the % enrichment of a variable of interest
var from baseline to treatment group.
But many rows with
var = 0 will be lost.
Moreover, I cannot compare % enrichment by dividing
Control/baseline::var because I will run into the problem of dividing by zero.
I've seen people circumvent this problem by adding a small value ex)0.01 to the entire column of
But I'm wondering if there's a better way of circumventing this problem. For example, a simple transformation that can deal with zeros and negative values.
Appreciate any input!