Using NCBI Gene database, I retrieved list of 7015 protein which are implicated in autism pathogenesis. This list includes tax-ID, organism name, symbol, aliases, map location, chromosome, genomic nucleotide accession version, start position on genomic accession, end position on genomic accession, orientation, exon count and OMIM). Among these 7015, 1144 proteins are involved in neurodevelopmental functions. I want to know that how many of these 1144 proteins are functionally similar to 7015 proteins? Is there a method to query 1144 proteins against 7015 proteins and group them based on structural similarity/ function similarity/ gene family?. Since I have large set of proteins, I am trying to understand if sub-set of proteins share similar function with this large set of proteins.