I have 40 samples and these are into two groups. I would like to perform a differential analysis between two groups. The library size of the samples is very low. But there are two samples (GroupA_12 and GroupB_2) in which the number of counts is too large compared to other samples. Please check the library sizes below:
I wanted to downsample these two cases and then would like to perform differential analysis. May I know how to downsample those two samples.
Any help is appreciated. thanq.