To begin with I have two nucleotide sequence to compare I want to see how they might have evolved in terms of sequence similarity and differences. One of the way i can think of is align the sequences. But i m not getting how do i associate it with mutation.
Now question is how do i know about mutation. I have the respective amino acid data from which i know there been mutation which is making changes how the binding happens between two sequences.
So now i have to associate nucleotide mutation with amino acid sequence data.
Any suggestion or help would be really appreciated. As always if there is a
R way to performing the analysis then it would be really good.