I am using fgsea in r to calculate and plot a bunch of GSEA graphs.
My question is whether it is acceptable to use the Wald statistic from DeSeq2 to rank the gene list?
I have seen in the GSEA application that the signal to noise ratio is used but is the Wald statistic sufficient?
If not then is there an easyish way to calculate the signal to noise ratio in R given a normalised count matrix?
Thanks in advance.