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In a genomic study of patients infected with SARS-CoV-2, the authors detected cross-replicating associations with rs11385942 at locus 3p21.31 , the association signal spanned the genes SLC6A20, LZTFL1, CCR9, FYCO1, CXCR6 and XCR1

I would like to know what's a cross-replication association.

Source pdf is here

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Replication in GWAS is an analytical term, approximating to 'robustness'. It is not biological phenomenon of a genome replicating. What the authors are saying is these genes associate with an allelic variant(s) which correlate with the disease phenotypic of COVID-19.

Three of those genes are very interesting indeed notably CCR9, CXCR6 and XCR1, because these are chemokine receptors. The later for example is associated with regulating between the innate and adaptive (CD8+, i.e. cytotoxic T-cell) immune responses (described in the image below). The innate/adaptive interface is an extremely trendy area in immunology.

The authors are implying the immunological signalling associated with one or more of these chemokines is fundamental to combating COVID-19 infection. 'Replication' is simply the GWA geek for 'its real'.

XCR1

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