# How do I download the mitochondrial haplogroup datasets for human genetics online?

I seem to have landed on the mitomap.org site, but I don't know what to make of it or what do with it / how to get the genomes onto my computer. It sounds like the genomes are stored in GenBank, but that mitomap simply lists which of the GenBank genomes are human mitochondrial haplogroup genomes.

First of all, I can't find a simple list of links or list of names of the haplogroups the mitomap has... Can you show me where I can get or download that? They say:

This brings our total number of FL sequences to 51,673, and the number of CR sequences to 74,660. Our SNVs now total 19,227.

I don't know what FL or CR (Control Region sequences?) means, but I am expecting to see lists of genomes or something. What am I to do with this information? Where do I find this data? Is this it? If I click on one of the results, I see this. It has path nuccore/MT742594.1, can I find this in some NCBI FTP server somewhere? I don't see anything of that folder structure in the GenBank FTP server...

Basically my question is:

1. Where is the complete list of human mitochondrial haplogroup genomes?
2. Where can I download all of those human mitochondrial haplogroup genomes so I can get them onto my computer?
• There is no such thing as "list of human mitochondrial haplogroup genomes". A haplogroup is not a genome but a list of variants common for many genomes. Oct 31, 2020 at 20:24
• Data is located here: mitomap.org/foswiki/bin/view/MITOMAP/Mitobank. Under the Sequences available column, you can download a text file containing genbank_id. You need to write a script to download all these files. My back of the envelope calculation suggest you will download about 1GB data. I suggest test few entry first. Mar 26 at 3:51
• Just realized this entry is very old :) Mar 26 at 3:52

Hmmm, I am not experienced enough in biology or bioinformatics to truly understand the question, but I am guessing you want to download the FASTA file or genebank file containing the sequence of the accession number you listed above. There are 2 ways to do this -

1. Using your browser, if you want to download a small sample of files. On the right hand side of your screen you can see the "send to" button on this link, click on it and choose the what's appropriate for you and then click on create file.

https://www.ncbi.nlm.nih.gov/nuccore/MT742594.1

1. If you familiar with Biopython and python programming you can download multiple files at once in whatever format you want, there is an easy script to do this and has been taken from Biopython's documentation on biopython.org

import os

from Bio import SeqIO

from Bio import Entrez

Entrez.email = "A.N.Other@example.com" # Always tell NCBI who you are

filename = "MT742594.1.gb"

if not os.path.isfile(filename):

 # Downloading...

net_handle = Entrez.efetch(

db="nucleotide", id="MG762674", rettype="gb", retmode="text"

)
out_handle = open(filename, "w")

out_handle.close()

net_handle.close()

print("Saved")


print("Parsing...")

• The easiest thing to do is just wrap 3 ` symbols before and after the code. Oct 31, 2020 at 18:50