I'am comparing bats coronavirus with Sars2, i.e. COVID-19. I have one question...

  • one Bat Sars coronaviurs identify in GenBank as DQ071615.1 has the ORF13(28122..28415) and ORF14(28572..28784) proteins
  • Sars2 identify in GenBank as MN908947_3, has range 28284..28577 not labeled as ORF13 and the same 28734..28955 is not labeled as ORF14?

The ORF13(28122..28415) of Bat coronavirus and PSEUDO_ORF13(28284..28577) of sars2 share 72% homology and ORF14(28572..28784) of Bat coronavirus and PSEUDO_ORF14(28734..28955) of sars2 share 75% homology

This seems one publication for ORF14 and ORF13 in Bat Viruses and relations in Sars2 here

The author say that ORF14 in Sars2 is all contained in N protein... And ORF13 is know in that above link as ORF9B and in that written is said ORF9B is implied in immunitary innate suppression...

  • $\begingroup$ Key to the answer is whether Rp3 is a Chinese bat virus ... I think the virus was originally part of this study science.sciencemag.org/content/310/5748/676 If you can tell me its country of origin .. if its Europe or Africa that would explain it. $\endgroup$ – M__ Nov 23 '20 at 12:10
  • $\begingroup$ i remember only i was surprised orf1ab was so different from sars2. And has in orf3 one 7 letter amminoacid chain that i was sarching in common with ebola (if i remember well) $\endgroup$ – RosLuP Nov 23 '20 at 21:12

The virus Rp3 stands for Rhi pea isolated in China in 2004.

The trees is here and groups with the Bulgarian sarbecoviruses and is closely related to the African sarbecoviruses. Thus although it is a Chinese sarbecovirus is not with the "Chinease originating" clade as is SARS and Covid-19.

Thats why the more mysterious ORFs ORF13 and 14 are missing, because over notable genetic distances these genes along with ORF10 are present/absent. This is a common feature of the betacoronaviruses.

In summmary this virus is notably distance from the major human pathogenic SARS/covid-19 viruses. Thus the absence of these auxilary genes isn't really surprising.

Its the very last taxa on the SARS-related viruses clade (monophyly) and is in a different group to SARS, which is the Beta-1 clade on this most excellent paper.

To answer the comment. They are outgroups, basically ancestral to COVID-19 and SARS-1 clade. So they lost these genes whilst the ingroup including COVID-109 and SARS-1 retained ORF13, 14 ... but I think lost ORF10 from memory

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  • $\begingroup$ "Thats why the more mysterious ORFs ORF13 and 14 are missing, because over notable genetic distances these genes along with ORF10 are present/absen"... the distance of what? >70% the same $\endgroup$ – RosLuP Nov 23 '20 at 22:35
  • $\begingroup$ 70% is a lot, post modified above. $\endgroup$ – M__ Nov 23 '20 at 22:37

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