What is the origin of HIV1?

This is the alignment of a small part of the POL protein of the HIV1 virus GenBank KU749412.1, with the POL protein of the Visna virus GenBank L06906.1

|||| | ||| | ||||||| | |  | ||| ||| ||  || || || |||||  || |  | || |    |  ||  |  ||   ||||||| |||  |  | |||       | |    |||| | ||||  |      || |                                | |||| ||  |   |||      | |  ||||                 

Are these matches,

  • By chance or convergence,
  • HIV1 and Visna virus share a recent common ancestor or,
  • the common ancestor was closer Visna virus from where HIV descended?

Could it be that HIV1 really comes from some kind of experiment involving Visna virus, as I read on the Internet?

The disease caused by the Visna virus is (100% deadly see https://pubmed.ncbi.nlm.nih.gov/16425963/ ). Could there be parallels to sars2?

But look at it: the Visna virus is transmitted by air the first symptoms are like pneumonia (or a brain infection) and otherwise are chronic progressing slowly like SARS-CoV-2 infection resulting in long Covid.

Symptoms are also felt after many days that the virus has come into action, this seems to me not to happen for coronaviruses or for flu viruses but for HIV and Visna virus.

Related links:

  1. https://pubmed.ncbi.nlm.nih.gov/8289690/

  2. https://pubmed.ncbi.nlm.nih.gov/16425963/

  3. (preprint sars2 as retrovirus) https://www.biorxiv.org/content/10.1101/2020.12.12.422516v1

  4. https://www.gao.gov/assets/100/91319.html


1 Answer 1


They are both lentiviruses and share a distant common ancestor.

HIV-1 and HIV-2 are descendents from simian immunodeficiency virus (SIV). The following tree shows the relationships very clearly, from Wertheim and Worobey (2009) Dating the Age of the SIV Lineages That Gave Rise to HIV-1 and HIV-2 PLoS Comp Biol. here. The evolution of HIV-1 is heavily mixed with chimanpzee (cpz) SIV, and there are regions of highly anomalous homology juxtaposed with regions of notably lower homology.

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  • $\begingroup$ and where it came from "SIVcol" and what is his genome? $\endgroup$
    – RosLuP
    Dec 17, 2020 at 11:32
  • $\begingroup$ Colobus monkey retrovirology.biomedcentral.com/articles/10.1186/… $\endgroup$
    – M__
    Dec 17, 2020 at 13:25
  • $\begingroup$ so you say visna->siv->HIV1 & HIV2? what about the chain is reversed visna->HIV1 & HIV2 ->SIV $\endgroup$
    – RosLuP
    Dec 17, 2020 at 22:55
  • 1
    $\begingroup$ No, he's saying OriginalLentivirus->SIV/HIV and OriginalLentivirus->visna. $\endgroup$
    – mgkrebbs
    Dec 18, 2020 at 4:25
  • $\begingroup$ So seems to me understand genome SIVcol can be find in GenBank with number AF301156.1 (SIVcolCGU1), with other SIVcol gag protein KF214242.1, with other SIVcol partial genome KF214241.1, the one base to all SIV Tree. SIVcol the one all other SIV they claim came from, right? $\endgroup$
    – RosLuP
    Dec 18, 2020 at 10:16

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