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I want to do meta-analysis of alpha diversity between test and control groups across 10 different populations. I want to see what is the summed effect (pool effect) of intervention between the two groups for alpha diversity. For that, first I need the intervention effect on test group's alpha diversity for individual population dataset. How should I calculate this? Should I calculate this by difference in the log transformed mean values of the groups (log2FC) or should I calculate SMD for each study? Thanks

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  • $\begingroup$ Cross-posted on biostars: biostars.org/p/9468060 $\endgroup$
    – Ram RS
    May 16, 2021 at 15:27
  • $\begingroup$ what is the measure of alpha-diversity? counts or proportion? $\endgroup$
    – Subhash C. Davar
    Feb 9, 2022 at 21:54

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