All the long-read sequencing platforms are based on single-molecule sequencing which causes higher per-base error rates. For this reason a polishing step was added to genome assembly pipelines - mapping raw reads back to assembly and correcting details of the assembly.
I have decent PacBio RSII dataset of single individual genome of heavily heterozygous non-model species. Assembly went well, but when I tried to polish the assembly using quiver it could not converge over a couple of iterations and I bet it is because of too great divergence of haplotypes.
Is there any other way to polish a genome with such properties? For instance, is there a way to separate long reads by haplotype, so I could polish using one haplotype only?