# FindMarkers from Seurat returns p values as 0 for highly significant genes

I have been working on FindMarkers function for identifying significant genes in the cluster. But some Significant genes have very low p values, so they are returned as 0 in the output.Any value less than the .machine\$double.xmin limit on R(that is 1e-305). So this output cannot be used for further plots like Volcano plots for visualization. Any solution to get p values for all the genes?

cd4.markers <- FindMarkers(sc.combined, ident.1 = "CD4+ T cell", min.pct = 0.25)


Part of the cd4.markers output

• you can add some constant to those columns
– kcm
Nov 17 '21 at 10:55
• Since other values are proportionally related, if we use a constant those genes forms a cluster. -Thanks Nov 17 '21 at 13:37