Background My understanding was that if I did scATAC-seq and I have some clusters of cell groups, the only way I can label it is by correlating those groups with scRNA-seq data.

My lab ordered some scATAC-seq data and the vendor did some complimentary analysis and provided cell composition plots indicating which portion of the cells of type X, Y, Z, so on.

Question How is this possible to identity cell composition identifying given cell types? Alternatively is it possible they just used some default RNA-seq data from 10x genomics?


scATAC-seq stands for "Single-cell sequencing assay for transposase-accessible chromatin" This attempts to consider genome-wide regulatory landscapes in single cells. scATAC-seq data can be sparse and noisy presenting a challenge for analysis.



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