I need beginner-level study materials for coarse-grained modeling of proteins.

Can anyone supply me with entry level resources besides the Wikipedia article?


Coarse grain protein modelling could be very broadly defined as an approximation of all-atom protein models and find current application in folding studies but are early approaches extend back to 1975.

Citing a recent review where comments in brackets are for elucidation and are not part of the citation.

Native structures (proteins) are not completely fixed, but they change when proteins perform their biological function, interact with other biomacromolecules, or undergo unfolding–folding transitions (for example conformational changes). Computational modeling of these processes is crucial for ... (examples truncated). Classical atom-level molecular modeling can address many of the these tasks, but its practical applications are still limited by its algorithmic efficiency and the available computing power.

Kmiecik et al "Coarse-Grained Protein Models and Their Applications" Chem. Rev. 2016, 116, 14, 7898–7936 https://doi.org/10.1021/acs.chemrev.6b00163



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