A question to those who have experience with MetaCache (metagenomic tool):
I have tried to build the MetaCache taxonomy from refseq (only bacteria), as described in the EXAMPLES here. However, the process turned out to be excruciatingly long, and I eventually gave up waiting after a week, reaching the progress of only 45%. I am using a 32-core server and the MetaCache seemed to make use of at least 16 cores, so I am puzzled by such slowness.
Is this normal behavior? Are there ways to do this faster or pre-built (relatively recent) databases? Is there a specific MetaCache forum, where I could pose a question to the developers?
MetaCache is a classifier in the Kraken mould. Here's the blurb.
Metagenomic shotgun sequencing studies are becoming increasingly popular with prominent examples including the sequencing of human microbiomes and diverse environments.
As a result, MetaCache consumes significantly less memory compared to the state-of-the-art read classifiers Kraken and CLARK while achieving highly competitive sensitivity and precision at comparable speed.