I was wondering if somebody here has experience with installing scvi-tools on a Mac with M1 chip. I tried the following command:

conda install scvi-tools -c conda-forge

But got the following error:

Collecting package metadata (current_repodata.json): failed
CondaSSLError: OpenSSL appears to be unavailable on this machine. OpenSSL is required to
download and install packages.
Exception: HTTPSConnectionPool(host='conda.anaconda.org', port=443): Max retries exceeded with url: /conda-forge/osx-64/current_repodata.json (Caused by SSLError("Can't connect to HTTPS URL because the SSL module is not available."))

Then I tried to install OpenSSL with following command:

conda install -c anaconda openssl 

and I got the exact same error as the conda install scvi-tools -c conda-forge command.

I do not understand why collection of metadata is failing for openssl. Any inputs would be highly helpful. Thanks!

  • $\begingroup$ There might be system incompatibilities, thats what my error log suggests. Thus I was unable to easily install as well. However this might be a Python version issue (could be Python 3.6, I used 3.11 [not the best idea]). However the error log should have flagged that. scvi-tools is a bioinformatics tool, but please try and edit the question with the biological problem. I'd guess this is RNA-seq PCA type analysis $\endgroup$
    – M__
    Nov 30, 2022 at 22:10
  • $\begingroup$ Wait, how did you end up with a non-working conda install on that M1 mac in the first place? Looks like it's not complaining about a missing package dependency; it's complaining about not having openssl to do HTTPS downloads within conda. $\endgroup$
    – Jesse
    Dec 1, 2022 at 22:44

1 Answer 1


Did you try:

pip install scvi-tools


  • 1
    $\begingroup$ Would need venv (virtual env) with pip, but I agree I think this is the best approach in this particular scenario $\endgroup$
    – M__
    Nov 30, 2022 at 22:33
  • $\begingroup$ scvi-tools.org $\endgroup$ Dec 1, 2022 at 10:51

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