I am relatively new to genome analysis and would like to compare 30+ vcf files, 1 sample per file. After filtering there are about ~20 variants per vcf file.
I would like to evaluate to mutational landscape between samples and for each sample as well.
One option that I found is a mutation heatmap where each row is a sample and each column a position in the genome. Is this the preferred way of displaying this type of information and how would I include gene information?
At this point I am interested in getting an overview first of the affected positions and then dig deeper using e.g. zygosity.
Thank you very much for helping out!
2nd edit I would also like to evaluate if there is a bias towards certain genes. For example are certain oncogenes mutated more frequently in this cohort or is the accumulation random and unique within each sample?