I would be thankful to you if you can help with the statistical approach for case-control study to link DNA methylation (epic array) with toxic element exposure (arsenic) and health outcome (Cardiovascular diseases).
I do have data from 125 Cardiovascular diseases and 125 non-Cardiovascular diseases individuals matched with age, sex, and smoking.I do have phenotypes files in a csv format having sex, age, smoking, disease, samples id, iAs (arsenic) values in log format and then a separate files for methylation data.
- The sample size is small.
- Maybe structural equation modelling could be used to find CpG sites associated with arsenic exposure and disease condition as I have very small size samples
- R is a preferred language.