I have not found any work which investigates assessment of differences in levels of secreted proteins by taking advantage of differential expression of the genes which mediate the secretory pathway.
For example, suppose the gene whose product binds specifically to a certain signal peptide is down-regulated. I would assume that this implies a down-regulation in all the levels of secreted proteins to which it binds.
Is such an analysis possible to date? If so, where?
Thanks in advance.