Is there a way to estimate the size of a BAM file will have after mapping with BWA?
The input file are two mates fastq files, compressed with gzip, each one about 70G.
Bioinformatics Stack Exchange is a question and answer site for researchers, developers, students, teachers, and end users interested in bioinformatics. It only takes a minute to sign up.
Sign up to join this communityA BAM file should have a roughly similar size to a compressed FASTQ file, because they're both compressed files that contain similar information. BAM will be slightly larger, because it contains information about mapping and differences from the reference.
If you are concerned about space and have a reference sequence available, you can store mapped reads as CRAM format, which will save a lot more space.