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How do I know if it is a AND or OR relationship between genes associated with the same enzyme in KEGG? E.g., for EC:1.6.1.2 (http://www.genome.jp/dbget-bin/www_bget?ec:1.6.1.2) does the bacterium Streptomyces coelicolor (SCO) need SCO7622 AND SCO7623 or SCO7622 OR SCO7623? enter image description here

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The enzyme EC:1.6.1.2 is an NAD(P) transhydrogenase and consists of two subunits. The two subunits are encoded by two different genes pntA and pntB.

So in terms of computer logic I would say AND, both subunits are necessary for a functional NAD(P) transhydrogenase enzyme (EC:1.6.1.2).

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  • $\begingroup$ This was only an example, is there a way of knowing in general? $\endgroup$
    – 5norre
    Dec 12 '17 at 15:13
  • $\begingroup$ With enzymes from KEGG there is not, I am afraid. In your example it becomes clear that we see 2 subunits, and hence form the same protein. However, if you look for example at human isocitrate dehydrogenase (IDH) EC 1.1.1.42, you will see that two different genes (IDH1 and IDH2) are listed. These 2 genes are not subunits of the same protein but are 2 different proteins (one in mitochondrium and the other in cytosol). With KEGG the interest in enzyme, not gene. $\endgroup$
    – benn
    Dec 12 '17 at 15:23

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