I am trying to understand the working of MutSigCV. But I am not sure about some terms used in MAF file format which is category.
According to MutSigCV, every mutation can be divided into the following categories:
- CpG transitions
- CpG transversions
- C: G transitions
- C: G transversions
- A: T transitions
- A: T transversions
- null+indel mutations
I am very much clear about some of this categories like C: G transitions and A: T transitions but for rest, I am unable to make any solid conceptual background. Can anyone suggest me the proper definition of these categories of mutations with proper examples?
MutSig stands for "Mutation Significance" and is defined here