I am in the process of conducting research on a wide array of proteins that are all post-translationally modified by the human enzyme GSK-3beta. What is the best to show (using peer-reviewed research as proof) that these proteins are in fact modified by GSK-3beta? There are over 50 proteins, and searching for them one by one would take longer than the time I have alotted for the research. Please provide a website/ database that can show this connection, or how to best make this connection.

  • $\begingroup$ In what species? Has there been any work on all of these? How did you collect your candidates? $\endgroup$ – terdon Jul 12 '18 at 12:39
  • $\begingroup$ Such a database is unlikely to exist. Have you searched for a paper doing a screen? That'd have this data in one spot. $\endgroup$ – Devon Ryan Jul 12 '18 at 12:39
  • $\begingroup$ BTW, you should be able to go through the literature for all 50 proteins and find this within a day, which isn't really a big time commitment. $\endgroup$ – Devon Ryan Jul 12 '18 at 12:41
  • $\begingroup$ Perhaps what I mean is that I roughly know how many proteins are associated with GSK-3B, however, do not know if my list of proteins is exhaustive. Is there any resource that provides all known products of the given enzyme? $\endgroup$ – Maslin Jul 12 '18 at 12:45
  • $\begingroup$ Have you checked protein-protein interaction databases? That should at least give you a list of proteins that can be modified by the enzyme. $\endgroup$ – terdon Jul 12 '18 at 13:03

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