SAMtools returned an error message for my gzipped genome FASTA:
Indexed block-compressed FASTA file cannot be handled
The source code for the message is here.
// check if the it is a valid block-compressed file
if (IOUtil.isBlockCompressed(path, true)) {
throw new SAMException("Indexed block-compressed FASTA file cannot be handled: " + path);
}
What's a "block-compressed" file?