I had a set of genes for honey bees. I found the homologues of those genes in the house fly and created a network of the honey bee genes and a network of the homologous fly genes using STRING.
I know that I could do a topological comparison between the networks and check if the same set of genes give the same hubs when in two different species. However, I can't find a single study where something similar has been done.
What biological inference can I draw from the topological parameters? For example, if the diameter of the fly network is smaller than the honey bee network, what inference could I draw?
UPDATE: It would be great if atleast some publications could be given where network comparisons have been done between different species.