I am trying to calculate the ΔG of TM insertion for many protein sequences.

Has anyone come across the source code or a programmatic version for the von Heijne ΔG for TM insertion? The web server is at http://dgpred.cbr.su.se/index.php?p=instructions

I can't find a link in the papers or on the site.

  • $\begingroup$ Ask the authors otherwise you'll require a "digger", (web spider). I'll share my "digger" code for another delta G website but I have not used this specific site. I think it is common for web servers not to distribute the "backend" for delta G calculations. If you get the standalone please post back. I'm about to start a very similar project (not on TM, but stability of a single antigen) and coding to explore the delta G parameter space is of a lot of interest $\endgroup$
    – M__
    Commented Mar 15, 2019 at 13:05
  • $\begingroup$ @MichaelG. Contacting the authors is the next step. I just want to check that I'm not missing their repo. A digger/scraper isn't ideal, unfortunately. The tool I'm building needs to be a bit of futureproof. $\endgroup$
    – James
    Commented Mar 15, 2019 at 14:34

1 Answer 1


The application is stored in github (ElofssonLab/dgpred) with a link to the website.

To find it I searched for: dgpred download github


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