I'm a novice trying to wrap my head around with fancy jargons. If I search residual, I understand that it represents the difference between the observed value of the dependent variable (y) and the predicted value (ŷ).
I'm unable to follow then, how are these residuals used as new phenotype?
I found similar question in the forum: Adjusting phenotypes by regressing out covariates
The origin of my question is predixcan pipeline, where residuals are used as the new gene expression values after regressing input values on covariates.