Questions tagged [machine-learning]
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1
vote
1answer
32 views
De novo motif discovery in protein sequences
I am trying to build a features matrix to be used for Random Forest based classification. I'd like to add, as features, short motifs which are common to all the protein sequences belonging to a ...
2
votes
1answer
74 views
Question about research in bioinformatics for Computer Science student [closed]
I am a computer science student, who was interested in taking research in the field of bioinformatics.
The first research idea I had was to make a model that could predict the possibility of type 2 ...
3
votes
1answer
95 views
Integrative analysis of omics studies using machine learning
I would like to use public omics datasets (ChIP-seq, RNA-seq, and ATAC-seq) from different studies to do an integrative analysis as follow:
Normalise samples, within each type of omics, from ...
3
votes
1answer
125 views
Machine learning using protein-sequences
I'm participating in a bioinformatics machine-learning seminar at my university. The main task is predicting binary classification of protein-protein interactions using sequence data as input.
One ...
1
vote
1answer
52 views
Link Prediction in Bipartite Networks between biological pathways and drugs
Currently I'm building a big matrix (using microarray, mass spectrometry, RNAseq data) that consist by pathways (rows) and treatment/drugs (columns).
The values of that matrix are scores that ...
1
vote
1answer
30 views
Proteins that cannot form biofilm?
I am trying to build a machine learning training set for bacterial protein sequences that form biofilm, and that cannot. I collected the positive sequences from the GO ontology website but for ...
2
votes
0answers
274 views
How to prevent sklearn Imputer(missing_values=“NaN”, strategy=“mean”, axis=0).fit_transform(data) from removing columns with only NA in them [closed]
I am trying to test a preexisting python machine learning script with a subset of my genetic data. One of the feature columns I am using happens to only have NA values in it. I lose this column when ...
3
votes
1answer
102 views
Preparing binary matrix data for Scikit classification algorithms
I made this post in regular stack overflow but I was told about this awesome feature by @nbryans.
I am a researcher (my programming knowledge is small) conducting analysis on a set of antibiotic (...
5
votes
2answers
200 views
Rule Extraction from nnet results
I used a script in R language that uses nnet library to predict promoter bacteria and i would like to know how to extract rules from this neural network results.
As my input of the neural network i ...
4
votes
2answers
101 views
How can I use annotations to remove variants not relevant to cancer risk?
I currently have ~180 whole germlines and around 10M SNPs/indels. I would like to build a predictive model using Machine Learning (ML) techniques to predict cancer risk according to these germline ...
