Questions tagged [storage]

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14 votes
5 answers

Good / recommended way to archive fastq and bam files?

We have a lot of Illumina sequenced exome data. Currently we are using spring for its great lossless compression, but we are looking if there is anything better (and most preferably opensource) which ...
Karthik Nair's user avatar
11 votes
2 answers

Do variant calls change when you call from CRAM?

We're considering switching our storage format from BAM to CRAM. We work with human cancer samples, which may have very low prevalence variants (i.e. not diploid frequency). If we use lossy CRAM to ...
morgantaschuk's user avatar
52 votes
9 answers

What's the most efficient file format for the storage of DNA sequences?

I'd like to learn which format is most commonly used for storing the full human genome sequence (4 letters without a quality score) and why. I assume that storing it in plain-text format would be ...
kenorb's user avatar
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