Questions tagged [storage]

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11
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2answers
283 views

Do variant calls change when you call from CRAM?

We're considering switching our storage format from BAM to CRAM. We work with human cancer samples, which may have very low prevalence variants (i.e. not diploid frequency). If we use lossy CRAM to ...
49
votes
8answers
5k views

What's the most efficient file format for the storage of DNA sequences?

I'd like to learn which format is most commonly used for storing the full human genome sequence (4 letters without a quality score) and why. I assume that storing it in plain-text format would be ...