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Cleb
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How to retrieve logical expression (KO based) for reactions from KEGG?

Whether a module is complete can easily be checked by evaluating the Definition entry associated with the module; e.g. in module M00010, it is given by

Definition  K01647 (K01681,K01682) (K00031,K00030)

which can be translated to

K01647 AND (K01681 OR K01682) AND (K00031 OR K00030)

If this expression evaluates to TRUE, the module is complete.

I am wondering whether analogue information exists for a single reaction. So e.g. for R00352, one finds the following information about Orthology:

enter image description here

But how do I now know in which logical relation the KOs are?

So it could be

K01648 AND K15230 AND K15231 

or

K01648 OR K15230 OR K15231

or

K01648 OR (K15230 AND K15231)

and so on.

In the above example, the correct expression would be:

K01648 OR (K15230 AND K15231)

One either needs K01648 or the other two subunits together.

Can this information be retrieved from KEGG for each reaction and if so, how?

Cleb
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