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Refers to large-scale genomic variation in a population or between individuals, including inversions, translocations, and copy number variants

Structural variants are genetic variants that involve large rearrangements of genomic sequence. There is no universal consensus as to what qualifies as "large", though 1kb and 10kb are commonly used as lower thresholds.

The term "structural variant" is used to distinguish large-scale variation from smaller variants such as single-nucleotide substitutions and short indels which are less disruptive to the genome structure.