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Methylation can be cell-specific, which makes it difficult to evaluate accuracy on a bulk-cell level (even within the same tissue). How can you tell that the differences you're seeing are due to platform differences, or due to biological variation? I find that adding more haystacks doesn't help much in working out the truth of a dataset. If you want to ...


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I would assess directionality and accuracy of prediction by 1) WGBS predicting ONT and then 2) ONT predicting WGBS. Firstly, I would use deep learning (or machine learning) and train WGBS against ONT, parameterise and then test. Then conversely train ONT against WGBS, parameterise and then test. The approach with highest accuracy of prediction (using the '...


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